No. Site Scan is offered as Software as a Service (SaaS) - Esri provides all storage and computing resources for you. Users of the Site Scan Manager web app can visualise and work with drone imagery and products without any other software.

However, there are cases where you may benefit from having additional ArcGIS products. Site Scan Manager can publish imagery directly to your ArcGIS Enterprise portal or ArcGIS Online organisation.

ArcGIS Pro and ArcGIS Image Server can be helpful for managing large data collections and sharing them as dynamic image services - benefits include consolidating many dates into one single image service layer, or adding raster functions for on-the-fly processing.